The Longitudinal Relationship of Hydroxyurea Adherence Behavior to Health-related Quality of Life, Barriers to Adherence and Habit Formation in Patients With Sickle Cell Disease.

About the study

The primary objective of this study is to better understand factors contributing to variations in hydroxyurea (HU) adherence behavior in adolescents and young adults (AYA) with sickle cell disease (SCD). To meet this objective, the researchers will conduct a prospective cohort study to determine the longitudinal relationship between HU adherence and health-related quality of life (HRQOL) overtime among AYA with SCD. The long-term goal of this research is to promote medication adherence behavior and improve health outcomes in AYA with SCD.

Study point of contact

Kathryn King, BS
(312) 227-4825
Sherif M. Badawy, MD, MS
(312) 227-4836


1 United States site


12 Years - 21 Years


Not Applicable

Study type






participation requirements

Age 12-21 years old
Any sickle cell disease genotype
On steady state of hydroxyurea for 2 months
Own or have access to a smartphone
Parents of patients that meet the eligibility criteria and are enrolled in the study will be included

participation restrictions

Patients with recent hospitalizations within the past 7 days


  • Chicago, Illinois, United States, Ann & Robert H Lurie Children's Hospital of Chicago, 60611 [Recruiting]
Last updated 2022-07-26