Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain).
49 United States sites
5 France sites
5 Spain sites
4 Greece sites
4 Italy sites
4 United Kingdom sites
3 Canada sites
2 Lebanon sites
2 Germany sites
12 Years - 65 Years
Phase 2/Phase 3
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive behavioral therapy (cCBT; n = 175) or digital education (m-Education; n = 175).
6 United States sites
> 18 Years
Not Applicable
Background: Venous thromboembolism (VTE) includes the abnormal clotting of blood in a deep vein of the upper or lower limbs (deep vein thrombosis) that may travel to and block a blood vessel in the lung (pulmonary embolism).
1 United States site
18 Years - 80 Years
HbSS, HbSC, HbAS
Background: Blood disorders like sickle cell disease and malaria affect many people around the world.
1 United States site
18 Years - 70 Years
The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters (non-elective infusion center/ER/hospital visits) or resulting in death over 12 months as compared with standard of care.
18 United States sites
1 United Kingdom site
1 France site
> 18 Years
Phase 3
Background: Sickle cell disease can often be treated with blood stem cell transplants.
1 United States site
4 Years - 80 Years
Phase 1/Phase 2
Background: Some people with the same disorder on a genetic level have more complications than others.
1 United States site
18 Years - 80 Years
This is an open label, multicenter, Phase 1/2 study in approximately eight adults with severe Sickle Cell Disease (SCD).
6 United States sites
18 Years - 40 Years
HbSS
Phase 1/Phase 2
This is a study testing the effects of behavioral sleep interventions on pain and brain function in sickle cell disease.
1 United States site
18 Years - 100 Years
Hemoglobin SC
Not Applicable
Background: - Some sickle cell disease or beta-thalassemia can be cured with transplant.
1 United States site
> 4 Years
Hb SS
Phase 2
