Sickle Cell Hemoglobinopathies and Bone Heath

About the study

This research study has two purposes. The first purpose is to determine whether having sickle
cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than
expected. Nearly 10% of African Americans (AA) carry sickle cell trait and most of them are
unaware of it. African Americans are less likely to develop thin bones than whites, but if
they sustain a bone fracture, they are more likely to die from it. We believe having sickle
cell trait may lead to bone thinning and predispose a subset of African Americans to
dangerously thin bones. The second purpose is to try to understand why individuals with
sickle cell disease (SCD) have thinner bones than healthy individuals do. Doctors have
already discovered that people with sickle cell disease have very thin bones, but they have
not determined why. Our study will try to identify whether the bone thinning is from the body
not making enough bone or from the body losing bone once it is made.

Study point of contact

Quratulain Ali, MPH, CCRP


1 United States site


18 to 45 Years

Study type








participation requirements

– Age 18-45 years.

– Female.

– Regular menstrual periods.

– Self-identification of African American race.

participation restrictions

– Taking oral contraceptives or medications known to influence bone metabolism (e.g.
Glucocorticoids, anti-resorptive or anabolic medications for osteoporosis,
pharmacologic Vit D dosing).

– Known metabolic bone disorder (e.g. uncontrolled thyroid disease,

– Pregnant, breast-feeding, or within 3 months post-partum.

– Taking an investigational drug.


  • Farmington, Connecticut, United States, UConn Health, 06032 [Recruiting]
Last updated 2021-06-18