To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
| Stella Chou, MD | |
| 215-590-0947 | |
| chous@chop.edu |
1 United States site
> 1 Year Years
Early Phase 1
Interventional
All
Biological
Subjects age >12 months
Diagnosis of SCD, all genotypes
Require a period of chronic red cell transfusion therapy
Rare RH genotype that would preclude identification of sufficient RBC units
Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
Alloimmunized to D antigen
Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols