To determine the feasibility of matching donor red cells by RH genotype for a cohort of
chronically transfused patients with SCD.
| Stella Chou, MD | |
| 215-590-0947 | |
| chous@chop.edu |
| Stacey Uter, BS | |
| 215-590-7722 | |
| uters@chop.edu |
1 United States site
> 1 Years
Early Phase 1
Interventional
All
Biological
Unknown
– Subjects age >12 months
– Diagnosis of SCD, all genotypes
– Require a period of chronic red cell transfusion therapy
– Rare RH genotype that would preclude identification of sufficient RBC units
– Antigen negative requirements due to alloimmunization that would preclude
identification of sufficient RBC units
– Alloimmunized to D antigen
– Rh alloimmunized patients for whom providing RH genotype matched blood would expose
the patient to an antigen that would not be consistent with standard of care and blood
bank protocols