Hemoglobin Desaturation and RBC Adhesion: Potential Therapeutic Targets in Sickle Cell Disease

About the study

As part of routine care for SCD, some people are found to have low oxygen levels (≤ 88%)
while sleeping, at rest, or with exercise. Testing is done with a small portable device
positioned on the finger that measures oxygen levels during sleep, at rest, or following
exercise. The investigators start oxygen treatment for people with low levels of oxygen. As a
part of this study, the investigators will find out if any changes in cell “stickiness” occur
with low oxygen levels (at rest, at night, or with exertion) and if cells become “less
sticky” with oxygen treatment. Study subjects will be seen before testing and 2 months after
testing. In some cases (people with low oxygen levels during testing), study subjects will
have been prescribed oxygen, and the investigators will test the effects of that treatment on
the stickiness of red cells.

Study point of contact

Jane Little, MD


1 United States site


> 18 Years



Study type






participation requirements

1. Male or Female > 18 year of age at the time of consent.

2. Documentation of Sickle Cell Disease, phenotypically HbSS (including S-Beta 0

3. Written informed consent (and assent when applicable) obtained from subject or
subject’s legal representative and ability for subject to comply with the requirements
of the study.

4. English speaking patient

participation restrictions

1. Ongoing Oxygen therapy.

2. active pregnancy, due to complex pathophysiology during that interval.

3. Presence of a condition or abnormality that in the opinion of the Investigator would
compromise the safety of the patient or the quality of the data. –


  • Cleveland, Ohio, United States, University Hospitals Cleveland Medical Center, 44106 [Recruiting]
Last updated 2019-04-05