Heart, Arteries and Sikle Cell Disease, a Multicentric Cohort of Cardiovascular Complications in Subsaharan Africa

About the study

The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries. The aim of this project is to describe the incidence and assess the predictive factors of SCD-related micro- and macro-vascular complications in sub-Saharan Africa.

Study point of contact

Louise Boyer-Chatenet, MS
Brigitte Ranque, MD PhD


4 Cameroon sites

3 Senegal sites

2 Côte D'Ivoire sites

2 Mali sites

1 Congo, The Democratic Republic of the site

1 Gabon site


> 5 Years

Study type

Observational [Patient Registry]



participation requirements

age: five-year-old or more
signature of informed consent Patients : major sickle cell syndrome confirmed by hemoglobin phenotyping: SS, SC, SBeta+ or Sbeta0 Controls : healthy parents or siblings of the patients, hospital staff or their children, matched on age+/- 3 years and country (1 control for 4 patients)

participation restrictions

unstable clinical status such as:

vaso-occlusive crisis in the previous 15 days
fever or infectious disease in the previous 15 days
transfusion in the previous 2 months


  • Yaounde, Cameroon, Central Hospital of Yaounde [Recruiting]
  • Yaounde, Cameroon, Centre mère et enfant / fondation Chantal Biya [Recruiting]
  • Yaounde, Cameroon, Centre Pasteur du Cameroun [Recruiting]
  • Yaounde, Cameroon, Pediatrics unit, Centre Hospitalier d'Essos [Recruiting]
  • Kinshasa, Congo, The Democratic Republic of the, Centre hospitalier Monkole [Recruiting]
  • Abidjan, Côte D'Ivoire, Hematology Unit, CHU Yopougon [Recruiting]
  • Abidjan, Côte D'Ivoire, Institut de cardiologie [Active, not recruiting]
  • Libreville, Gabon, CIRMF [Completed]
  • Bamako, Mali, Cardiology Unit, Centre gyneco-obstretrique [Active, not recruiting]
  • Bamako, Mali, Centre de Recherche et de Lutte contre la Drepanocytose [Recruiting]
  • Dakar, Senegal, Centre hospitalier d'enfants Albert Royer [Recruiting]
  • Dakar, Senegal, Centre hospitalo-universotaire de Fann, Cardiology department [Recruiting]
  • Dakar, Senegal, Centre national de transfusion sanguine [Recruiting]
Last updated 2018-05-24