Efficacy of Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients : A Randomized, Double-blind, Two-armed Parallel-group, Placebo-controlled Phase II/III Study – Khartoum, Sudan

About the study

To study the efficacy of Gum Arabic as an anti-oxidant, anti-inflammatory and Fetal
Hemoglobin-inducing agent among Sickle Cell Disease children. Half of participants will
receive Gum Arabic and the other half will receive placebo

Study point of contact

Lamis AA KAddam, PhD
+249912979736
lamiskaddam@hotmail.com
Dalya MM Abdelmaged, MBBS
00249126831595
dalya.alfeel@gmail.com

Locations

1 Sudan site

Age

3 to 18 Years

Phase

Phase 2/Phase 3

Study type

Interventional

Gender

All

Interventions

Dietary Supplement

Compensation

Unknown

participation requirements

– Homozygous for Sickle Cell Disease (SS) as documented by Haemoglobin electrophoresis.

Subjects whom medications and dosages had been stable for 2 weeks before study entry.

Subjects who have not received blood transfusion or had acute episode related to sickle
cell disease in the last two weeks before the start of intervention.

participation restrictions

– Patients with history of Gum Arabic allergy. Patients who have ischemic heart disease,
liver dysfunction or hepatitis. Pregnant female patients who plan to conceive in the
next 4 months and fertile female patients who are not using an effective contraception
method.

Patients who are currently using Gum Arabic. Patients who are on steroids or chemotherapy.

Locations

  • Omdurman, Khartoum, Sudan, Military Hospital, 1113 [Recruiting]
Last updated 2020-01-26