Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)

About the study

The purpose of this study is to determine if a search strategy of searching for an HLA-matched unrelated donor for allogeneic transplantation if possible then an alternative donor if an HLA-matched unrelated donor is not available versus proceeding directly to an alternative donor transplant will result in better survival for allogeneic transplant recipients within 2 years after study enrollment.

Study point of contact

Erin Leckrone
Jenny Vogel


52 United States sites


Not Applicable

Study type








participation requirements

Patients fulfilling the inclusion criteria will be eligible for enrollment in this study. Of those who consent, only patients who lack a suitable HLA-identical or 1 allele or antigen mismatched related donors are evaluable. Patients with an HLA-identical sibling or 1 allele or antigen mismatched family member donor are evaluable as long as the center deems the family member donor as unsuitable for other reasons. Patients may co-enroll with other interventional or observational studies.

Patients of all ages with AML, ALL, MDS, NHL, HL, AA, or SCD are eligible.
Any planned conditioning regimen and GVHD prophylaxis approach is eligible.
Patients must be considered suitable allogeneic transplant candidates at the time of enrollment based on medical history, physical examination, and available laboratory tests. Specific testing for organ function is not required for eligibility but, if available, these tests should be used by the treating physician to judge transplant suitability.
Patient and physician must intend to proceed with allogeneic HCT within the next 6 months if a suitable donor is identified.
Center plans to follow the algorithm for alternative donor identification: (a) for subjects who are Very Likely to find a MUD, attempt to identify a matched unrelated donor; (b) for a subjects who are Very Unlikely to find a MUD, proceed expeditiously to a haploidentical, cord blood or mismatched unrelated donor.
Signed informed consent, and assent if applicable. Consent may be signed prior to completion of family typing but patients will only be considered evaluable upon confirmation that there is no suitable HLA-identical or 1 allele or antigen mismatched related donor available.

participation restrictions

Prior allogeneic HCT (prior autologous transplant is allowed)
Previous formal unrelated donor search


  • Duarte, California, United States, City of Hope, 91010 [Recruiting]
  • La Jolla, California, United States, University of California, San Diego Medical Center, 92093 [Recruiting]
  • Los Angeles, California, United States, Children's Hospital Los Angeles, 90027 [Recruiting]
  • Stanford, California, United States, Stanford Hospitals and Clinics, 94305 [Recruiting]
  • Washington, District of Columbia, United States, Children's National Medical Center, 20010 [Recruiting]
  • Gainesville, Florida, United States, University of Florida, 32610 [Recruiting]
  • Miami, Florida, United States, University of Miami, 33136 [Recruiting]
  • Pembroke Pines, Florida, United States, Memorial Healthcare System, 33028 [Recruiting]
  • Tampa, Florida, United States, H. Lee Moffitt Cancer Center, 33612 [Recruiting]
  • Atlanta, Georgia, United States, Children's Healthcare of Atlanta, 30322 [Recruiting]
  • Atlanta, Georgia, United States, Emory University, 30322 [Recruiting]
  • Atlanta, Georgia, United States, Northside Hospital, 30342 [Recruiting]
  • Maywood, Illinois, United States, Loyola University, 60153 [Recruiting]
  • Indianapolis, Indiana, United States, Indiana University, 46202 [Recruiting]
  • Baltimore, Maryland, United States, University of Maryland, 21201 [Recruiting]
  • Boston, Massachusetts, United States, Dana Farber Cancer Institute, 02215 [Recruiting]
  • Ann Arbor, Michigan, United States, University of Michigan, 48109 [Recruiting]
  • Detroit, Michigan, United States, Karmanos Cancer Institute, 48201 [Recruiting]
  • Minneapolis, Minnesota, United States, University of Minnesota, 55414 [Recruiting]
  • Rochester, Minnesota, United States, Mayo Clinic Rochester, 55905 [Recruiting]
  • Jackson, Mississippi, United States, University of Mississippi, 39216 [Recruiting]
  • Kansas City, Missouri, United States, Children's Mercy Hospital, 64108 [Recruiting]
  • Saint Louis, Missouri, United States, St. Louis Children's Hospital, 63110 [Recruiting]
  • Saint Louis, Missouri, United States, Washington University in St. Louis, 63110 [Recruiting]
  • Omaha, Nebraska, United States, University of Nebraska Medical Center - Adults, 68105 [Recruiting]
  • Omaha, Nebraska, United States, University of Nebraska Medical Center - Pediatrics, 68105 [Recruiting]
  • Buffalo, New York, United States, Rosewell Park Cancer Institute, 14263 [Recruiting]
  • New York, New York, United States, Mount Sinai Medical Center, 10029 [Recruiting]
  • New York, New York, United States, Memorial Sloan Kettering Cancer Center, 10065 [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina, 27599 [Recruiting]
  • Charlotte, North Carolina, United States, Levine Cancer Institute, 28204 [Recruiting]
  • Durham, North Carolina, United States, Duke University Medical Center, 27710 [Recruiting]
  • Winston-Salem, North Carolina, United States, Wake Forest Baptist Health, 27157 [Recruiting]
  • Cleveland, Ohio, United States, University Hospitals Cleveland Medical Center, 44106 [Recruiting]
  • Cleveland, Ohio, United States, Cleveland Clinic, 44195 [Recruiting]
  • Columbus, Ohio, United States, Nationwide Children's Hospital, 43205 [Withdrawn]
  • Columbus, Ohio, United States, The Ohio State University, 43210 [Recruiting]
  • Oklahoma City, Oklahoma, United States, University of Oklahoma, 73104 [Recruiting]
  • Portland, Oregon, United States, Oregon Health and Science University, 97239 [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia, 19104 [Recruiting]
  • Philadelphia, Pennsylvania, United States, University of Pennsylvania, 19104 [Recruiting]
  • Charleston, South Carolina, United States, Medical University of South Carolina, 29425 [Recruiting]
  • Dallas, Texas, United States, Children's Medical Center Dallas, 75235 [Recruiting]
  • Fort Worth, Texas, United States, Cook Children's Medical Center, 76104 [Recruiting]
  • Houston, Texas, United States, Baylor College of Medicine, 77030 [Recruiting]
  • Houston, Texas, United States, M.D. Anderson Cancer Center, 77030 [Recruiting]
  • Salt Lake City, Utah, United States, University of Utah, 84113 [Recruiting]
  • Charlottesville, Virginia, United States, University of Virginia, 22903 [Recruiting]
  • Richmond, Virginia, United States, Virginia Commonwealth University, 23298 [Recruiting]
  • Seattle, Washington, United States, Fred Hutchinson Cancer Research Center, 98109 [Recruiting]
  • Madison, Wisconsin, United States, University of Wisconsin, 53792 [Recruiting]
  • Milwaukee, Wisconsin, United States, Medical College of Wisconsin, 53226 [Recruiting]
Last updated 2022-03-07