1 United States site
> 7 Years
Diagnosis of sickle cell disease (genotype SS, SC, or SB0), thalassemia (transfusion dependent or transfusion independent), or normal control subject that are ≥18yrs, ethnicity, and sex matched to the sickle cell disease population.
Ability to tolerate a one hour MRI examination.
Age equal to or greater than 7 years old for Anemia groups.
Agreeable to use an approved method of contraception for the entire duration of hydroxyurea usage if accepted onto the hydroxyurea substudy (male or female of childbearing potential)
Hospitalization within one month
Contraindication to acetazolamide use (seizures)
Pregnancy or nursing (a negative HCG (pregnancy) test must be obtained prior to MRI)
As a result of medical review, physical examination or screening investigations, the Principal Investigator (PI) considers the subject unfit for the study
No fixed address
In control subjects, chronic hepatitis, diabetes, hypertension, coronary artery disease, cognitively impaired or developmental delay